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化妆品皮肤学12.pdf
RETINOIDS
類A
924118009盧
/
RETINOIDS類A
/
參料
() (六)量
() ()
() ()
()RETINOIDS臨 ( )RXR
() 參料
A Retinoids 療
老
1986年 Kligman
Retinoids
復度
良
• Daily topical application of 0.05% tretinoin in a cream base was
compared with its vehicle with regard to moderation of photoaging
changes of the face and forearms. In comparison with the control
tissue, tretinoin-treated tissue examined by light and electron
microscopy showed the following effects: replacement of the atrophic
epidermis by hyperplasia, elimination of dysplasia and atypia,
eradication of microscopic actinic keratoses, uniform dispersion of
melanin granules, new collagen formation in the papillary dermis, new
vessel formation (angiogenesis), and exfoliation of retained horn in the
follicles. Physiologic studies demonstrated: increased blood flow and
dermal clearance, increased transepidermal water loss, and greater
permeability and reactivity. It was concluded that topical tretinoin is
capable of at least partly reversing the structural damages of
excessive sunlight exposure and may be useful in decelerating the
photoaging process.
類A
A RARs
類
RAR RAR RAR
17q.21 3P.24 12q.13
P 24
21 13
q
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