Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 1300.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis The CRYSTMAS study.docVIP

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Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 1300.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis The CRYSTMAS study.doc

Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 1300.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis The CRYSTMAS study

Guidetetal.CriticalCare2012,16:R94 /content/16/3/R94 RESEARCH OpenAccess Assessmentofhemodynamicefficacyandsafety of6%hydroxyethylstarch130/0.4vs.0.9%NaCl fluidreplacementinpatientswithseveresepsis: TheCRYSTMASstudy BertrandGuidet1,2,3*,OlivierMartinet4,ThierryBoulain5,FrancoisPhilippart6,7,JeanFran?oisPoussel8,JulienMaizel9, XavierForceville10,MarcFeissel11,MichelHasselmann4,AlexandraHeininger12andHugoVanAken13 Abstract Introduction:Inadequateinitialtreatmentanddelayedhemodynamicstabilization(HDS)maybeassociatedwith increasedriskofdeathinseveresepsispatients. Methods:Inordertocomparethehemo

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