Association of MHC and rheumatoid arthritis HLA polymorphisms in phenotypic variants of rheumatoid arthritis.docVIP

/content/2/3/212 Review Association of MHC and rheumatoid arthritis HLA polymorphisms in phenotypic variants of rheumatoid arthritis Cornelia M Weyand and J?rg J Goronzy Mayo Clinic and Foundation, Rochester, Minnesota, USA Received: 19 January 2000 Accepted: 29 February 2000 Published: 19 April 2000 Arthritis Res 2000,2:212–216 ? Current Science Ltd Abstract Genes in the human leukocyte antigen (HLA) region remain the most powerful disease risk genes in rheumatoid arthritis (RA). Several allelic variants of HLA-DRB1 genes have been associated with RA, supporting a role for T-cell r