Bench-to-bedside review Targeting antioxidants to mitochondria in sepsis.docVIP

Galley Critical Care 2010,14:230 /content/14/4/230 RE VIE W Bench-to-bedside review: Targeting antioxidants to mitochondria in sepsis Helen F Galley* major target [2,3]. Mitochondria produce more than 90% Abstract of the body’s cellular energy in the form of ATP via Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. Under normal circumstances, complex interacting antioxidant defense systems control oxidative stress within mitochondria. However, no studies have yet provided conclusive evidence