原创力文档Case report of a young child with disseminated histoplasmosis and review of hyper immunoglobulin e syndrome (HIES).docVIP
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Case report of a young child with disseminated histoplasmosis and review of hyper immunoglobulin e syndrome (HIES)
Robinsonetal.ClinicalandMolecularAllergy2011,9:14
/content/9/1/14
CMA
REVIEW
OpenAccess
Casereportofayoungchildwithdisseminated
histoplasmosisandreviewofhyper
immunoglobulinesyndrome(HIES)
WilsonSRobinson1,2?,SandraRArnold1,2?,ChristieFMichael1,2,JohnDVickery1,RobertASchoumacher2,
EnikoKPivnick2,JewellCWard2,VijayaNagabhushanam3andDukheeBLew1,2*
Abstract
Type1hyperIgEsyndrome(HIES),alsoknownasJob’sSyndrome,isanautosomaldominantdisorderdueto
defectsinSTAT3signalingandTh17differentiation.Symptomsmaypresentduringinfancybutdiagnosisisoften
madeinchildhoodorlater.HIESischaracterizedbyimmunologica
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