CCR5 From Natural Resistance to a New Anti-HIV Strategy.docVIP

Viruses 2010, 2, 574-600; doi:10.3390/v2020574 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review CCR5: From Natural Resistance to a New Anti-HIV Strategy Lucia Lopalco Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, via Stamira D’Ancona, 20, 20127 Milan, Italy; E-Mail: lopalco.lucia@hsr.it; Tel.: +39-02-2643-7936; Fax: +39-02-2643-5381 Received: 23 October 2009; in revised form: 22 December 2009 / Accepted: 4 February 2010 / Published: 5 February 2010 Abstract: The C-C chemokine receptor type 5 (CCR5) is a key player in HIV infec