CD16 (FcRγIII) as a potential marker of osteoclast precursors in psoriatic arthritis.docVIP

Chiuetal.ArthritisResearchTherapy2010,12:R14 /content/12/1/R14 RESEARCH ARTICLE OpenAccess CD16(FcRgIII)asapotentialmarkerofosteoclast precursorsinpsoriaticarthritis YahuiGraceChiu1,2,TianmengShao3,ChangyongFeng4,KofiAMensah2,5,MichaelThullen2, EdwardMSchwarz2,5,ChristopherTRitchlin1,2* Abstract Introduction:Psoriaticarthritis(PsA)isachronicinflammatoryarthritischaracterizedbyboneerosionmediatedby osteoclasts(OC).OurpreviousstudiesshowedanelevatedfrequencyofOCprecursors(OCP)inPsApatients.Here, weexaminedifOCarisefromCD16-positivemonocytesinPsA. Methods:Peripheralbloodmononuclearcells(PBMC)o