原创力文档Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans.docVIP
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Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans
Bergetal.CriticalCare2010,14:R16
/content/14/1/R16
RESEARCH
OpenAccess
Cerebralnetexchangeoflargeneutralamino
acidsafterlipopolysaccharideinfusioninhealthy
humans
RonanMGBerg1*,SarahTaudorf1,DamianMBailey2,CarstenLundby3,FinStolzeLarsen4,
BenteKlarlundPedersen1,3,KirstenM?ller1,5
Abstract
Introduction:Alterationsincirculatinglargeneutralaminoacids(LNAAs),leadingtoadecreaseintheplasmaratio
betweenbranched-chainandaromaticaminoacids(BCAA/AAAratio),maybeinvolvedinsepsis-associated
encephalopathy.WehypothesisedthatadecreaseintheBCAA/AAAratiooccursalongwithanetcerebralinfluxof
theneurotoxicAAAphe
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