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Characterizing operant hyperactivity in the Spontaneously Hypertensive Rat
Hilletal.BehavioralandBrainFunctions2012,8:5
/content/8/1/5
RESEARCH
OpenAccess
Characterizingoperanthyperactivityinthe
SpontaneouslyHypertensiveRat
JadeCHill,KatrinaHerbstandFedericoSanabria*
Abstract
Background:Operanthyperactivity,theemissionofreinforcedresponsesataninordinatelyhighrate,hasbeen
reportedinchildrenwithADHDandintheSpontaneouslyHypertensiveRat(SHR),themostwidelystudiedanimal
modelofADHD.TheSHRemitsbehaviorathyperactivelevels,relativetoanormoactivestrain,onlywhensuch
behaviorisseldomreinforced.Becauseofitsdependenceonrateofreinforcement,operanthyperactivityappears
tobedrivenpr
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