Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review.docVIP

Xingetal.CriticalCare2012,16:R7 /content/16/1/R7 RESEARCH OpenAccess Clinicalutilityofbiomarkersofendothelial activationinsepsis-asystematicreview KatharineXing1,SrinivasMurthy2,WConradLiles3,4 andJeffreyMSingh4,5* Abstract Introduction:Astrongbiologicrationaleexistsfortargetingmarkersofendothelialcell(EC)activationasclinically informativebiomarkerstoimprovediagnosis,prognosticevaluationorrisk-stratificationofpatientswithsepsis. Methods:TheobjectivewastoreviewtheliteratureontheuseofmarkersofECactivationasprognostic biomarkersinsepsis.MEDLINEwassearchedforpublicationsusingthekeyword‘sepsis