Comparing cellular proteomes by mass spectrometry.docVIP

Minireview Comparing cellular proteomes by mass spectrometry Florian Fr?hlich and Tobias C Walther Address: Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried/Munich, Germany. Correspondence: Tobias C Walther. Email: twalther@biochem.mpg.de Abstract Identifying proteins by mass spectrometry Intact proteins are difficult to identify by MS because their sequence cannot be obtained by fragmentation and so Mass spectrometry and cryo-electron tomography together enable the determination of the absolute and relat