原创力文档Composite effects of gene determinants on the translation speed and density of ribosomes.docVIP
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Composite effects of gene determinants on the translation speed and density of ribosomes
Tulleretal.GenomeBiology2011,12:R110
/2011/12/11/R110
RESEARCH
OpenAccess
Compositeeffectsofgenedeterminantsonthe
translationspeedanddensityofribosomes
TamirTuller1*?,IsanaVeksler-Lublinsky2?,NirGazit3,MartinKupiec4,EytanRuppin3,5 andMichalZiv-Ukelson2
Abstract
Background:Translationisacentralprocessoflife,anditsregulationiscrucialforcellgrowth.Inthisarticle,
focusingontwomodelorganisms,EscherichiacoliandSaccharomycescerevisiae,westudyhowthreemajorlocal
featuresofagene’scodingsequence(itsadaptationtothetRNApool,itsaminoacidcharge,anditsmRNAfolding
energy)affectitstranslationelongation.
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