Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites.docVIP
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Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
Beteletal.GenomeBiology2010,11:R90
/2010/11/8/R90
METHOD
OpenAccess
ComprehensivemodelingofmicroRNAtargets
predictsfunctionalnon-conservedand
non-canonicalsites
DoronBetel1,AnjaliKoppal2,PhaedraAgius1,ChrisSander1,ChristinaLeslie 1*
Abstract
mirSVRisanewmachinelearningmethodforrankingmicroRNAtargetsitesbyadown-regulationscore.Thealgo-
rithmtrainsaregressionmodelonsequenceandcontextualfeaturesextractedfrommiRanda-predictedtarget
sites.Inalarge-scaleevaluation,miRanda-mirSVRiscompetitivewithothertargetpredictionmethodsinidentifying
targetgenesandpredictingtheextentoftheirdownregulation
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