Confirmation of a low HER2 positivity rate of breast carcinomas - limitations of immunohistochemistry and in situ hybridization.docVIP

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Confirmation of a low HER2 positivity rate of breast carcinomas - limitations of immunohistochemistry and in situ hybridization.doc

Confirmation of a low HER2 positivity rate of breast carcinomas - limitations of immunohistochemistry and in situ hybridization

VogelDiagnosticPathology2010,5:50 /content/5/1/50 RESEARCH OpenAccess ConfirmationofalowHER2positivityrateof breastcarcinomas-limitationsof immunohistochemistryandinsituhybridization UlrichFVogel Abstract Background:Accurateassessmentofthehumanepidermalgrowthfactorreceptor2(HER2)ofinvasivebreast cancerisessentialtotreatmentdecisionssincetheadventoftargetedtherapywiththehumanizedmonoclonal antibodytrastuzumabandthedualtyrosinekinaseinhibitorlapatinib.Intheliterature,thepercentageofHER2- overexpressed/amplifiedbreastcarcinomasrangefrom3%to30%.Theroutinelyassignedlowrateof9%ofHER2- overexpresse

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Confirmation of a low HER2 positivity rate of breast carcinomas - limitations of immunohistochemistry and in situ hybridization.docVIP