原创力文档Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5.docVIP
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Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5
Petsanisetal.BMCPhysiology2012,12:5
/1472-6793/12/5
RESEARCH ARTICLE
OpenAccess
Contractilepropertiesandmovementbehaviour
inneonatalratswithaxotomy,treatedwiththe
NMDAantagonistDAP5
KonstantinosPetsanis1?,AthanasiosChatzisotiriou1*?,DorotheaKapoukranidou1,ConstantinaSimeonidou2,
DimitriosKouvelas3andMariaAlbani1
Abstract
Background:Itiswellknownthataxotomyintheneonatalperiodcausesmassivelossofmotoneurons,whichis
reflectedinthereductionofthenumberofmotorunitsandthealterationinmuscleproperties.Thistypeof
neuronaldeathisattributedtotheexcessiveactivationoftheionotropicglutamatereceptors(glutam
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