Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones a co-culture study.docVIP

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Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones a co-culture study.doc

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Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones a co-culture study

Available online /content/9/1/R6 Research article Open Access Vol 9 No 1 Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture study Gisela Segond von Banchet1, Jonny Richter1, Marion Hückel2,3, Christina Rose3, Rolf Br?uer3 and Hans-Georg Schaible1 1Institute of Physiology, University of Jena, Teichgraben 8, D-07740 Jena, Germany 2Current address: Roche Diagnostics GmbH, D-82377 Penzberg, Germany 3Institute of Pathology, University of Jena, Ziegelmühlenweg, D-07740 Jena, Germany Corresponding author: Hans-Georg Schaible, Hans-Georg.Schaible@mti.uni-jena.de Received: 31 Aug 2006 Revisions requested: 3 Oct 2006 Revisions received: 20 Dec 2006 Accepted: 25 Jan 2007 Published: 25 Jan 2007 Arthritis Research Therapy 2007, 9:R6 (doi:10.1186/ar2112) This article is online at: /content/9/1/R6 ? 2007 Segond von Banchet et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Innervation of the joint with thinly myelinated and unmyelinated sensory nerve fibres is crucial for the occurrence of joint pain. During inflammation in the joint, sensory fibres show changes in the expression of receptors that are important for the activation and sensitization of the neurones and the generation of joint pain. We recently reported that both neurokinin 1 receptors and bradykinin 2 receptors are upregulated in dorsal root ganglion (DRG) neurones (the cell bodies of sensory fibres) in the course of acute and chronic antigen-induced arthritis in the rat. In this study, we begin to address mechanisms of the interaction between fibroblast-like synovial (FLS) cells and sensory neurones by establishing a co-cult