2真核细胞转录调控28.pptVIP

Deacetylation represses transcription. 6. Methylation of Histones DNA Is Connected Methylation of both DNA and specific sites on histones is a feature of inactive chromatin. The SET domain is part of the catalytic site of protein methyltransferases. The two types of methylation event are connected. Genome-wide distribution pattern of histone modifications. Reprinted from Cell, vol. 128, B. Li, M. Carey, and J. L. Workman, The Role of Chromatin during Transcription, pp. 707-719. Copyright 2007, with permission from Elsevier [/science/journal. 7.1 Promoter Activation Involves Multi