中科院细胞与分子免疫学课程课件6.pptVIP

* * * * * * * * * * * * * * * * * * * The major functions of T cell integrins are to mediate adhesion to APCs, endothelial cells and extracellular matrix proteins The avidity of integrins and the expression of integrins will be increased by: Inflammatory Cytokines TCR recognize antigen Integrin function: 1 retention of antigen-stimulated T cells in lymphoid organs 2 retention of activated T cells at peripheral sites of infection and antigen persistence Selectins and Selectin Ligands: Regulate the migration of leukocytes to various tissues. HEV Selectins and Selectin Ligands: L-selectin: is