The basic pathological changes of inflammation in the second section(国外英文资料).docVIP

The basic pathological changes of inflammation in the second section(国外英文资料) They are found in the cells of mast cells, platelets and intestinal mucosa. The main effect is to make the wall of the blood vessel wall permeability and low concentration. 2, arachidonic acid metabolites, prostaglandins and leukotrienes, arachidonic acid, arachidonic acid, AA) is 20 carbon unsaturated fatty acid, abound in the cell membrane phospholipids. When cells by certain stimulation or other medium and cell damage, cell of phospholipase (mainly from neutrophilic lysosome) is activated, prompting AA released from plasma membrane phospholipids. The AA is released, and immediately after a series of metabolic processes, it forms the prostaglandin and white blood cell. Prostaglandin (e.g., PGE2, PGI2) can cause vasodilation, increased permeability of blood vessel walls, moreover also can cause pain and fever, and the chemotaxis of neutrophils and eosinophils. Leukotrienes (e.g., LTB4) in inflammation mainly by raising the permeability of blood vessel walls, neutrophils and eosinophils have chemotaxis, clinical certain anti-inflammatory treatment, such as aspirin, indomethacin, by inhibiting the metabolism of AA, glucocorticoid make AA difficult to release from the phospholipids, reduce inflammation reactions. 3, lysosome composition in the process of inflammation, neutrophils and monocytes in the lysosome enzyme and non enzyme composition can be a medium of inflammation, including neutrophils cationic protein can make mast cell degranulation release of histamine, increased vascular permeability, and mononuclear macrophage chemotaxis; Neutral protease can degrade collagen, basal membrane, elastin and cellulose, causing tissue damage and promoting abscess formation. T lymphocyte cells of the lymphatic factor are exposed to the corresponding antigens again, which can release various lymphatic factors. If the macrophage activator is activated, the macrophage can be activated to increase its a