血尿酸在不同类型老年冠心病发生中的作用.docVIP

血尿酸在不同类型老年冠心病发生中的作用 　　作者：李晓英 　　【摘要】 目的 探讨血尿酸(UA)在不同类型老年冠心病发生中的作用。 方法 41例老年冠心病住院患者分为稳定型心绞痛组(SA)和急性冠脉综合征(ACS)组，测定 UA、血小板Α颗粒膜蛋白(GMP140)、血管性假性血友病因子(vWF)、纤溶酶原激活物抑制物1(PAI1)，血栓素B2(TXB2)、C反应蛋白(CRP)。 结果 ACS组血UA升高者CRP、TXB2高于血UA正常者(P0.05)，而SA组中各项指标在UA升高者与UA正常者之间差异无显著性。 结论 血UA升高可能通过激活血小板、引发炎症反应参与不同类型老年冠心病患者病情的发生与发展。 　　【关键词】 血尿酸 冠心病 老年人 　　Role of serum uric acid in different types of coronary heart disease in the elderly LI Xiaoying, YANG Ruiying, WU Hailiang. Department of General Medicine, the Affiliated Hospital of Ningxia Medical College,Yinchuan 750004, China; HOU Yuntian, Institute of Geriatric Cardiology of General Hospital of PLA,Beijing 100853, China; MA Cheng. the Fifth Hospital of PLA, Yinchuan 750004, China 　　【Abstract】　Objective To explore the effect of serum uric acid (UA) on different type of coronary heart disease (CHD) in the elderly. Methods Fortyone patients were divided into two groups: stable angina (SA) group and acute coronary syndrom (ACS) group. The levels of UA, alphagranule membrane protein 140(GMP140), von Willebrand factor(vWF), plasminogen activator inhabitor type1(PAI1)，thromboxane B2(TXB2)，Creactive protein(CRP) were measured. Then all data as well as intercommunication were evaluated among two groups. Results The levels of CRP and TXB2 of hyperuricemia patients were significantly higher than those of nonhyperuricemia patients in ACS group(P0.05). There was no significant difference in SA group possessing hyperuricemia and nonhyperuricemia (P0.05). Conclusions UA is an important risk factor in different types of CHD in the elderly. It can induce different CHD in the elderly by activating platelet, causing inflammatory process. 　　【Key　words】 serum uric acid; coronary heart disease; aged 　　近年来，随着人民生活水平的提高，饮食结构的变化，高尿酸(UA)血症的患病率也逐渐增加[12]。目前多数学者认为血UA是冠心病的危险因素，但血UA在不同类型老年冠心病中所发挥的不同作用国内外研究得较少。血管性假性血友病因子(vWF)、血小板Α颗粒膜蛋白(GMP140)、纤溶酶原激活物抑制物1(PAI1)、血栓素B 2(TXB2)分别是血管内皮功能受损、血小板激活的特异性标志物,C反应蛋白(CRP)是炎症反应的特异性标志物。本研究