白癜风诊治指南(国外英文资料).docVIP

白癜风诊治指南(国外英文资料) / A guide to vitiligo Introduction to disease Vitiligo (Vitiligo) is an acquired, localized or generalized skin pigmentation that is a common skin disease affecting beauty. The diagnosis is difficult, the Chinese medicine calls it white purpura or white breeze. [etiology] The cause of the disease is not clear. Recent studies have linked the following factors: Heredity theory Research suggests that vitiligo may be a skin disease of autosomal dominant inheritance. Foreign authors of 30% of patients had a positive family history and found that two of the identical twins were ill. Domestic reporting positive family history is 3% ~ 12%, lower than the foreign report. Autoimmune theory The relationship between autoimmune theory and vitiligo is becoming more and more important. Many scholars pay attention to the patients and their family members in the merger ratio is higher, autoimmune disease common thyroiditis, hyperthyroidism, or loss, diabetes, chronic adrenal hypofunction, pernicious anemia, rheumatoid arthritis, malignant melanoma, etc. And the serum of patients with vitiligo, someone check out multiple organ specificity of antibody, such as anti-thyroid antibodies, antibody of parietal cell antibody resistance, resistance to adrenal, parathyroid antibody resistance, resistance to smooth muscle antibodies, etc., and was much higher. The incidence of vitiligo was 10 to 15 times higher than in the general population with autoimmune diseases. Recently found vitiligo patients have resistance to melanin cell surface antigen antibody, called vitiligo antibody, the drop degree and the degree of the patients with skin depigmentation, drop degree increases with lesion area of expansion, also found that patients with vitiligo animal has a similar phenomenon, put forward that the disease is of melanocyte autoimmune diseases. Behl (1977) found that monocytes gathered on the edge of the active stage leukoplakia, invade the dermal epidermal junction, by the destr