SHARP试验补充材料.pdf

Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359:378-90. SUPPLEMENTARY APPENDIX A: DEFINITIONS AND DESCRIPTIONS OF INSTRUMENTS Table A1. Definitions of ECOG Performance Status15 Reproduced with permission from Lippincott Williams and Wilkins, on behalf of Wolters Kluwer Healthcare and the American Journal of Clinical Oncology Grade 0 Fully active, able to carry on all pre-disease performance without restriction 1 Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work 2 Ambulatory and capable of all selfcare but unable to carry out any work activities; up and about more than 50% of waking hours 3 Capable of only limited selfcare, confined to bed or chair for more than 50% of waking hours 4 Completely disabled. Cannot carry on any selfcare. Totally confined to bed or chair 5 Dead Table A2. Child–Pugh Classification.16,17 Copyright 1973, copyright British Journal of Surgery Society Ltd. Reproduced with permission. Permission is granted by John Wiley Sons Ltd on behalf of the BJSS Ltd. Score* Measure 1 point 2 points 3 points Ascites Absent Slight Moderate Serum bilirubin (mg/dL) 2.0 2.0–3.0 3.0 Serum albumin (g/dL) 3.5 2.8–3.5 2.8 Prothrombin time, sec (seconds 4