海洋细菌活性物质研究进展-Bacteria—AReview.PDF

Bioprocess 生物过程, 2012, 2, 7-12 /10.12677/bp.2012.21002 Published Online March 2012 (/journal/bp) Advances in the Bio-Active Products from Marine Bacteria—A Review * Bailiang Xu, Lianyun Wang State Key Laboratory of Microbial Metabolism and School of Life Sciences Biotechnology, Shanghai Jiao Tong University, Shanghai * Email: {xbliang, wanglianyun}@ Received: Oct. 15th, 2011; revised: Nov. 6th, 2011; accepted: Nov. 21st, 2011 Abstract: Ever-changing ocean environment has bred the extreme diversity of marine microorganisms. Recent re- searches showed that marine bacteria, the majority of the marine microorganism, generate abundant bio-active materials, indicating a foreseeable and great potential of the search for novel bio-active products from marine bacteria. This pro- gress has attracted attentions of both academia and business. Marine bacteria could become a new resource in drug screening and show a promising development prospect. Based on the recent works of bio-active material from marine bacteria, we reviewed their main features and active roles in the study of antibiotics, anti-tumor agents, enzyme and enzyme inhibitors, anti-inflammatory medicine and so on, revealing the current status of marine bacteria bio-active ma- terial in drug development. We summed up the problems encountered at this stage and made a prediction of probable hot spot in the future development. Keywords: Marine Bacteria; Bio-Active Products; Marine Drug 海洋细菌活性物质研究进展 徐佰亮，王莲芸* 上海交通大学生命科学与技术学院，微生物代谢国家重点实验室，上海