粒-巨噬细胞集落刺激因子吸入治疗复发性肺泡蛋白沉积症三.PDFVIP

中国呼吸与危重监护杂志 2017年3月第16卷第3期 • 277 •   ·论　　著· 粒细胞- 巨噬细胞集落刺激因子吸入治疗 复发性肺泡蛋白沉积症三例报告 李颖，刘浪，张晓华，罗光明，严薇，杨龙 湖南省职业病防治院（湖南长沙  410007 ） 【摘要】   目的    观察雾化吸入注射用重组人粒细胞-巨噬细胞集落刺激因子（GM-CSF ）治疗复发性肺泡蛋 白沉积症（PAP ）的疗效及安全性。方法    对 3 例确诊 PAP 并予以大容量全肺灌洗后复发的患者再予以雾化吸入 GM-CSF 治疗，对比治疗前后临床症状、肺部高分辨 CT 、肺功能及动脉血氧分压的临床数据，分析其治疗效果。 结果    3 例患者经过雾化吸入 GM-CSF 治疗后，临床症状减轻，肺部病变明显减少，动脉血氧分压、肺通气功能和 肺弥散功能均明显上升，治疗过程中，3 例患者均无不良反应。结论    雾化吸入 GM-CSF 治疗复发性 PAP 安全有 效，但远期效果还有待进一步观察。 【关键词】  肺泡蛋白沉积症；复发性；粒细胞-巨噬细胞集落刺激因子；雾化吸入 Therapeutic efficacy of GM-CSF inhalation in patients with recurrent pulmonary alveolar proteinosis LI Ying, LIU Lang, ZHANG Xiaohua, LUO Guangming, YAN Wei, YANG Long Hunan Prevention and Treatment Central for Occupational Diseases, Changsha, Hunan 410007, P.R.China Corresponding author: LI Ying, Email: liying9858@163.com 【Abstract 】 Objective    To evaluate therapeutic efficacy and safety of recombinant human granulocyte- macrophage colony-stimulating factor (GM-CSF) inhalation in patients with recurrent pulmonarv alveolar proteinosis (PAP). Methods    Three cases of recurrent PAP were treated by GM-CSF inhalation after whole lung lavage. The clinical data of the pulmonary function and SpO , the clinical symptoms and pulmonary lesions were compared before and after 2 treatment. Results    The pulmonary function and manifestations were improved obviously after GM-CSF inhalation. Also the ground-glass opacity was improved in high-resolution CT. The pulmonary function and SpO increased obviously 2 after received GM-CSF inhalation. There were no any adverse reactions in 3 cases. Conclusion    GM-CSF inhalation therap