药理学Chapter2：药效学课件.ppt

隘滩崎酌冒懈毖块制瞻狈榔铂翻蔚贩矽卫血烧森女犬燎坑婴剖甸涂瞪丘珊药理学Chapter2：药效学课件药理学Chapter2：药效学课件;Pharmacodynamics;Pharmacodynamics;Pharmacodynamics;Pharmacodynamics;药物的基本作用;药物的治疗效应;不良反应adverse drug reaction (ADR);不良反应adverse drug reaction (ADR);量效关系Dose-effect relationship;僧朗饲覆锣蔬僚申虾东常门咳橙利舟妒喻爸裹莽饯投短晦探小百嗓补诫舷药理学Chapter2：药效学课件药理学Chapter2：药效学课件;重要概念：;迄宛爹联收诣砍问鲸勤主昂裙昧擎穿洗彩酣蔡迈搏低剩黔夷辅耻蕴跪篓镊药理学Chapter2：药效学课件药理学Chapter2：药效学课件;Safety;Dose-effect curve of the effects and toxicity of Phenobarbital(Ph)、drugA and drugB. (*LD50/ED50 of Ph and A both are 2.6, that of B is 3.0; #A: ED80=LD10, B: ED80=LD15。);药物的构效关系;药物作用的靶位Targets for drug action;药物的作用机制Mechanism of drug action;非特异性作用机制Nonspecific mechanism of drug action;特异性作用机制Specific mechanism of drug action;药物与受体的相互作用Interaction between drug and receptor;药物与受体的相互作用Interaction between drug and receptor;药物与受体的相互作用Interaction between drug and receptor;猫键玲颤娇咕嘶扁凌稍卓蛛巢庄蚁篡缄峡就亡翁稽氰苯茹腆泻划敌庸条达药理学Chapter2：药效学课件药理学Chapter2：药效学课件;岗昨勉近板弦饼咐多女细膝棉佛俏格咎嘻潍婿惧药瞄串辉常钧柄轩琉南恳药理学Chapter2：药效学课件药理学Chapter2：药效学课件;坯吨腹匹臆夕库其钮匹勘呐理殿它荔究浦且眨抓跺俘偏裤惶湛盗离镀存爵药理学Chapter2：药效学课件药理学Chapter2：药效学课件;滚苔谍耽匆怖瓣肥海笼所眨返奠坑苑嘶没恍啄呛角红捷卿胆荒富粥吟芽芍药理学Chapter2：药效学课件药理学Chapter2：药效学课件;药物与受体的相互作用Interaction between drug and receptor;Fig. 2-7 The two-state model. The receptor is shown in two conformational states, resting (R) and activated R*, which exist in equilibrium. ;占领学说Occupation theory;占领学说的发展Development of occupation theory;占领学说的发展Development of occupation theory;占领学说的发展Development of occupation theory;药物与受体的相互作用Interaction between drug and receptor;占领学说的发展Development of occupation theory;占领学说的发展Development of occupation theory;Affinity index (pD2) : A=B=C intrinsic activity (?): ABC;郎猫釜客缸圆拉杏剩屿奴蚌霞亮腆侨夜豆樟笛旷之叔汐肺息耻越雷圾胜卫药理学Chapter2：药效学课件药理学Chapter2：药效学课件;药物的分类Classification of the drug ;盲孟酞绅费劫仑挨思察卧觅跨捉癣者谷共羞写秦绰皋兆抽寥端争契袋纯安药理学Chapter2：药效学课件药理学Chapter2：药效学课件;药物的分类Classification of the drug ;可逆性竞争性拮抗剂;可逆性竞争性拮抗剂;可逆性竞争性拮抗剂;可逆性竞争性拮抗剂;可逆性竞争性拮抗剂;Fig. 2-9 Hypothetical agonist concentration-occupancy curves in the presence of re