Trisomy 21-7年.pptVIP

21 Trisomy Syndrome CHEN Pu Pediatric Department, the First Affiliated Hospital, Medical College of ShanTou University. 21 Trisomy Syndrome Genetic disease: 1. Gene disorders 2. Somatic genetic disorders 3. Chromosome disorders Definition: 21 trisomy syndrome = Down syndrome Trisomy 21 is the most frequent and best known trisomy in humans and is associated with a characteristic set of congenital anomalies and mental retardation. Incidence: Males : Females = 3:2 1/ 800 or 1.25‰ newborns The occurrence of trisomy 21 increases with advancing maternal age ( 35 years) . Etiology: 21 T