肿瘤相关巨噬细胞在重塑肿瘤免疫微环境中作用.PDFVIP

922 　　肿瘤2013 年10 月第33 卷第10 期　TUM OR Vol. 33, October 2013 DOI: 10.3781/j .issn.1000-7431.2013.10.014 Copyright© 2013 by TUM OR Review 综述 · 肿瘤相关巨噬细胞在重塑肿瘤免疫微环境中的作用 郭秋均，李　杰 中国中医科学院广安门医院肿瘤科，北京　100053 [摘要]　肿瘤相关巨噬细胞在肿瘤间质中占有很大的比例。近年来诸多实验和临床研究均发现，肿瘤相关巨噬细 胞与肿瘤的生长和转移密切相关，其数量与肿瘤的恶性程度和不良预后相关，在肿瘤的侵袭和转移过程中起到了 促进作用。同时，巨噬细胞的可塑性也成为了改变肿瘤微环境和免疫重塑的肿瘤免疫治疗研究的热点。越来越多 的研究报道了肿瘤相关巨噬细胞对肿瘤微环境的影响，并提出基于肿瘤相关巨噬细胞的免疫治疗策略。本文即综 述了肿瘤相关巨噬细胞的来源和其抑制肿瘤免疫微环境、重塑肿瘤细胞外基质、促进肿瘤组织血管和淋巴管生成 以及针对肿瘤相关巨噬细胞靶点治疗等的研究进展。 [关键词]　肿瘤形成过程；巨噬细胞；肿瘤逃逸；免疫疗法，肿瘤；肿瘤微环境 [中图分类号]　R730.3 [文献标志码] A [文章编号]　1000-7431 (2013) 10-0922-06 The role of tumor-associated macrophages in remodeling tumor immune microenvironment GUO Qiu-jun, LI Jie Department of Oncology, Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China [A BSTRACT]　Majority of experimental and clinical studies have shown a pro-tumoral function of tumor- associated macrophages (TAMs) which occupy a large part in matrix cells. TAMs promote tumor cell invasion and migration, and their number is related to malignant degree and poor prognosis. Macrophages plasticity makes it possible to change the tumor microenvironment and remodel tumor immune in cancer immunotherapy. Increasing researches have revealed the TAMs effect on tumor microenvironment and put forward tumor immune treatments aiming at TAMs. Here this review presents the recent research of TAMs in remodeling tumor immune microenvironment and immune targeted therapies, such as the origin of TAMs, the immunosuppression effect of TAMs on tumor microenvironment, tumor extracellular matrix remodeling, and promotion of angiogenesis and lymphangiogenesis [KEY WORDS]　Neoplastic processes; Macrophages; Tumor escape; Immunotherapy, tumor; Neoplastic microenvironment