中国部分地区胎婴儿尿道下裂的相关因素分析论文.docVIP

　　中国部分地区胎婴儿尿道下裂的相关因素分析论文 靳蕾 洪世欣 郑俊池 章斐然 高进吉 冯振芳 张静波 张伯兰 叶荣伟 【摘要】 【摘要】 目的 分析尿道下裂相关因素，探索尿道下裂的病因。 方法 对江苏、浙江和河北省的27个县(市)以人群为基础的出生缺陷和围生保健监测系统中，1993年1月1日 ～ 2000年12月31日孕20周及以上到出生后42 d的590 042名男性胎婴儿的相关资料进行单因素和多因素Logistic回归分析。 结果 单因素分析发现家庭居住在南方、城市地区，母亲职业非农民和乡镇企业工人、母亲高中及以上文化程度，父亲职业非农民和乡镇企业工人，双胎或多胎，出生体重 2 500 g、足月低出生体重和早产是尿道下裂的相关因素(P 0.05)。多因素Logistic回归分析发现，南方地区尿道下裂的患病率高于北方(OR=2.051.freeline the factors associated ale births in some areas of China.MethodsThe data records of birth defects surveillance system in 27 cities and counties in Jiangsu, Zhejiang and Hebei Provinces in China during January 1, 1993 and December 31, 2000. The study population included all male live births，fetal deaths and still births ore aternal occupation ers or other iddle school, the paternal occupation ers or all for gestational age and preterm ale births (P 0.05). The results after adjusted the confounding effect ultivariate logistic model all for gestation age (OR=20.338，95 % CI：13.667-30.265) and preterm (OR=2.710，95 % CI：1.817-4.042) ale births.ConclusionsMore researches need to focus on the etiology and prevention of hypospadias in southern area in China, and small for gestation age and preterm may share the cauases J. Environ Health Perspect, 1999,(107):297302. 2Paulozzi LJ, Erickson JD, Jackson RJ. Hypospadias trends in ts J. Pediatrics, 1997,100:831834. 3Nelson CP, Park JM, . The ‘oestrogen hypothesis’ y, etiology, and technique J. J Pediatr Surg , 2006,41(3):463472. 9Carmichael SL, Shaiology J. Epidemiology, 2003,14(6):701706. 10Hughes IA, Northstone K, Golding J, et al. Reduced birth ichael SL, Shaalformations cooccurring J Med Ge A, 2007,143A(22):26272634. 13H, Baskin LS. Endocrine disruptors, genital development, and hypospadias J. J Androl, 2008,29(5):499505. 14郑俊池, 王红, 季成叶, 等. 围产保健与儿童保健监测的方法与应用J. 中华流行病学杂志, 2001,22(3):166168. 15Li S, Moore CA, Li Z, et al. A populationbased birth defects surveillance system in the People’s Republic of China J. Paediatric and Perinata