不同方法治疗难治性胃食管反流病疗效观察.docVIP

不同方法治疗难治性胃食管反流病疗效观察 　　【摘要】 目的 探讨不同方法治疗难治性胃食管反流病的临床疗效和安全性。方法 120例难治性胃食管反流病患者， 随机分为A组和B组， 每组60例。A组患者接受埃索美拉唑 + 莫沙必利治疗， B组患者接受埃索美拉唑 + 莫沙必利 + 铝碳酸镁治疗， 均持续治疗8周。对比分析两组患者的临床症状改善情况、临床疗效及不良反应发生情况。结果 治疗8周后， 两组患者烧心、反酸、胸骨后疼痛、嗳气的临床症状评分均低于治疗前， 且B组低于A组， 差异有统计学意义（P0.05）。结论 埃索美拉唑联合莫沙必利和铝碳酸镁治疗难治性胃食管反流病的疗效显著， 能够明显改善患者的临床症状， 且安全性较高， 在临床治疗难治性胃食管反流病时可考虑应用 【关键词】 难治性胃食管反流病；埃索美拉唑； 莫沙必利； 铝碳酸镁；疗效 DOI：10.14163/j.cnki.11-5547/r.2017.07.002 Curative effect observation on different methods in the treatment of refractory gastroesophageal reflux disease XU Bo-xing， LI Jia. Department of Gastroenterology， Gaozhou City Hospital of Traditional Chinese Medicine， Maoming 525200， China 【Abstract】 Objective To explore the clinical curative effect and safety of different methods in the treatment of refractory gastroesophageal reflux disease. Methods A total of refractory gastroesophageal reflux disease patients were randomly divided into group A and group B， with 60 cases in each group. Group A received esomeprazole + mosapride for treatment， group B received esomeprazole + mosapride + hydrotalcite for treatment. Both groups all received continuous treatment for 8 weeks. Comparison and analysis on clinical symptom improvement， clinical curative effect and occurrence of adverse reactions in two groups. Results After 8 weeks of treatment， both groups had lower clinical symptom score of heartburn， sour regurgitation， retrosternal pain， belching than before treatment， and group B had lower points than group A， and the difference had statistical significance （P0.05）. Conclusion Combination of esomeprazole， mosapride and hydrotalcite shows significant curative effect in treating refractory gastroesophageal reflux disease， and it can obviously improve the clinical symptoms in patients with high safety. So it is recommended to be used in the treatment of refractory gastroesophageal reflux disease in clinic. 　　铝碳酸镁为新型抗酸药， 具有中和胃酸和保护胃黏膜等作用， 此外， 铝碳酸镁的主要活性成分氢氧化镁铝能够吸附和结合胃蛋白酶而直接抑制其活性， 有利于溃疡面的修复， 也是治疗胃食管反流病的有效药