VEGF在原发性翼状胬肉组织中的表达与临床意义.pdfVIP

Hans Journal of Ophthalmology 眼科学, 2017, 6(1), 25-29 Published Online March 2017 in Hans. /journal/hjo /10.12677/hjo.2017.61005 Expression of VEGF in Primary Pterygium and Its Clinical Significance Huaiyun Jin, Jianfeng Wang* Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui th th st Received: Mar. 15 , 2017; accepted: Mar. 27 , 2017; published: Mar. 31 , 2017 Abstract Objective: To detect the expression of vascular endothelial growth factor (VEGF) in different parts of primary pterygium (head, neck and body) and normal conjunctiva, to explore its clinical signi- ficance in the mechanism of primary pterygium. Methods: Thirty-five pterygium tissue specimens and five normal conjunctival specimens were obtained during the surgery. The pterygium tissues were divided into three parts according to head, neck and body. The expressions of VEFG mRNA were detected by Real-time PCR. The differences of VEGF expression among different specimens were analysed and compared. Results: The expression of VEGF mRNA was detected in all parts of pterygium and normal conjunctiva, and the expression level of VEGF increased gradually from pterygium head to body. The expression of VEGF in pterygium body was significantly higher than that in the head and neck (P 0.001), and also higher than that in normal conjunctiva (P 0.05). There was no significant difference of VEGF expressions among head, neck and normal conjunctiva (P 0.05). Conclusion: The expression levels of VEGF in pterygium increased gradually from head to body, and the expression of VEGF in pterygium body was significantly higher than that in nor- mal conjunctiva. VEGF was over expressed in pterygium body.