神经修复学学科体系医若干问题探讨.pdfVIP

366 Chinese Journal of Reparative and Reconstructive Surgery, March 2009, Vol. 23, No.3 · · • 综 述 • 神经修复学学科体系若干问题探讨 陈琳 黄红云 【摘  要】    目的 探讨神经修复学学科体系中的若干核心问题。  方法 回顾神经修复学领域的发展历程和重 要科研成果，进行规律性总结、科学技术哲学归纳以及理论性升华。  结果 提出学科体系架构如下：①神经修复学学科 的基本内容：是一门研究神经再生、神经结构修补或替代、神经重塑、神经调控的神经科学亚学科，核心目标是促使神经退 行性变疾病和各类损害所致功能缺失的神经功能恢复。②神经修复学学科的“一个中心”和“两个基本点”：以修复神经 功能为研究的中心，基础神经修复和临床神经修复为两个基本点。③神经修复学学科体系的四大理论基础：有限修复论、 重新学习论、储备下降论、终生巩固论。④神经修复学的“五驾马车（5N 法则）”：神经再生、神经修补、神经重塑、神经调控、 神经康复。广义的概念还包括神经保护。⑤神经修复四部曲（四阶梯）理论：结构神经修复、信号神经修复、康复神经修复、 功能神经修复。⑥神经修复基础成果向临床应用的转化条件。  结论 神经修复学是一门新学科，具有广阔的发展前景， 将极大促进基础与临床的紧密结合和快速转化。 【关键词】 神经修复学 理论 再生 重塑 神经康复    神经调控 中图分类号：R741 R651 文献标志码：A NEURORESTORATOLOGY: NEW CONCEPT AND BRIDGE FROM BENCH TO BEDSIDE/ CHEN Lin, HUANG Hongyun. Beijing Hongtianji Neuroscience Academy, Department of Neurosurgery, Beijing Rehabilitation Center, Beijing, 100144, P.R.China. Corresponding author: HUANG Hongyun, E-mail: hongyunh@ 【Abstract 】    Objective  To elucidate the new concept and theory of neurorestoratology.  Methods  With the review of the development course and important research works in the field of neurorestoratology during the 20th century, especially recent 30 years, the regularity summary, science and technology philosophy induction, and theory distillation were carried out in this article.  Results  The new disci pline system was brought forward as follows: ① Definition: neurorestoratology was a sub-disci pline of neuroscience which studies neural regeneration, neural structural repair of replacement, neruroplasticity and neuromodulation. The core purpose was to promote neural functional recovery of all neural degenerative diseases and damages. ②One central task and two basic point