ATP敏感性钾通道在帕金森病中的作用.pdfVIP

370 Neuroscience Bulletin November 30， 2007，23(6)：370—376．http：／／www．neurosci．ca ·Minireview· ATP—sensitive potassium channels：novel po ntial roles in Parkinson’sles in arionson s 7 disease Jie ZENG ，Gang WANG ，Sheng—Di CHEN ， Department of Neurology and Neuroscience Institute，Ru(jin Hospital affiliated to Shanghai Jiaotong University School ofMedicine，Shanghai 200025,China 。Institute ofHealth Science，Shanghai Institutes ofBiological Sciences，Chinese Academy ofScience~Shanghai Jiaotong University School ofMedicine，Shanghai 200025,China Abstract：The ATP-sensitive potassium(KATe)channels which extensively distribute in diverse tissues fe．g．vascular smooth muscle，cardiac cells，and pancreas)are well—established for characteristics like vasodilatation，myocardial protec— tion against ischemia，and insulin secretion．Th e aim of this review is to get insight into the novel roles of K册 channels in Parkinson’s disease(PD)，with consideration of the specificities K channels in the central nervous system(CNS)， such as the control of neuronal excitability，action potential，mitochondrial function and neurotransmitter release． Keywords：ATP-sensitive potassium(K棚，)channels；Parkinson’s disease 1 Introduction neurotransmitter release in the central nervous system (CNS)have been compellingly recognized…．Due to their Parkinson’s disease(PD)is a most common movement diversity and distinct localizations，the KA channels are disorder caused by loss of dopaminergic neurons in the the interesting candidates for new therapeutic strategies． substantia