adc值测量对不同病理类型乳腺癌的诊断价值 - 中国骨质疏松杂志.doc

文献标识码：A 中图分类号：R318.08（生物材料学） CPC/PMMA双向骨水泥性能及生物相容性的初步研究 包利 唐海 王炳强 朱富强 董益鹏 邓介超 摘要 目的 材料与方法 1:2、1:1、2:1均匀混合，制成不同比例的混合骨水泥，然后将PMMA、CPC、混合骨水泥（1:2、1:1、2:1）制成标准试件（直径6mm、高12mm），最后对试件进行力学性能、凝固温度、凝固时间、电镜扫描、X线衍射、动物肌肉内植入实验，初步评估混合骨水泥的性能及生物相容性。 结果 结论 关键词 作者单位：首都医科大学附属北京友谊医院骨科 100050 作者简介：包利，男，1980年生，北京市人，汉族，2010年首都医科大学毕业，硕士。电子邮箱：baoli611980@ Preliminary study on biocompatibility and properties of CPC/PMMA (Dual-phase Bone Cement) Abstract Objective To develop an injectable mixture of bone cement that was made by polymethylmethacrylate cement (PMMA) and calcium phosphate cement (CPC). This mixed bone cement has the advantages of each material and can overcome the shortcomings of PMMA and CPC. We hope this mixed bone cement will become an ideal filling material for vertebroplasty and kyphoplasty. Methods Firstly, we mixed PMMA together with CPC by the mass ratio of 1:2, 1:1, 2:1 in order to produce mixed bone cements with different proportions. Secondly, we made the standard test pieces (diameter 6mm, high 12mm) by PMMA, CPC, mixed bone cement (1:2, 1:1, 2:1). Finally, we made a comprehensive assessment of physical and chemical properties of the mixed bone cement by carrying out tests on mechanical property, solidification temperature, solidification time, electron microscope scanning, X-ray diffraction and animal muscle implantation experiment. Results The mixed bone cement (1:1) had better physical and chemical properties than other propotions. Its compressive strength increased by about 120% higher than CPC, solidification temperature was lower than 45℃, and solidification time was about 12~14 min. The microscopic structure of this mixed bone cement (1:1) was similar to CPC, 70% of the total pores were between 100～300μm and between the pores had 10~20μm eyelet penetrations. The animal intramuscular implantation experiment demonstrated that the mixed bone cement (1:1) had good biocompatibility, but the degeneration speed was slow. Conclusion The mixed bone cement (1:1) cou