phosphor p70S6k、p70S6k 南京医科大学(英文版).PDFVIP

ARTICLE IN PRESS Neuropharmacology xxx (2010) 1e11 Contents lists available at ScienceDirect Neuropharmacology journal homepage: www.elsevi /locate/neuropharm DHEA prevents Ab25e35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling Liang Li a, Bingzhong Xu a, Ying Zhu a, Lei Chen a, Masahiro Sokabe b, Ling Chen a, b, * a Department of Physiology, Nanjing Medical University, Hanzhong Road 140, Jiangsu, China b Department of Physiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Nagoya 466-8550, Japan a r t i c l e i n f o a b s t r a c t Article history: Infusion (i.c.v.) of b-amyloid 25e35 (Ab25e35) stimulates proliferation of progenitor cells in the hippo- Received 21 October 2009 campal dentate gyrus (DG) of adult male mice, but a large population of the newborn cells will die in the Received in revised form 2nd week after birth, a critical period for neurite growth. Neurosteroid dehydroepiandrosterone (DHEA) 3 February 2010 has been demonstrated to promote neurite growth. Herein, we report that the DHEA-treatment on 6e12 Accepted 9 February 2010 days after BrdU-injection (BrdU-D6e12) dose-dependently attenuates the loss of newborn neurons induced by Ab25e35-infusion. The DHEA-neuroprotection was blocked by the s1 receptor antagonist Keywords: