复发性外阴阴道假丝酵母菌病菌种及药敏特征探究.doc

复发性外阴阴道假丝酵母菌病菌种及药敏特征探究【摘 要】 目的:了解假丝酵母菌在复发性外阴阴道假丝酵母菌病的菌种分布和药物敏感性，为临床治疗提供帮助。方法：收集108例复发性外阴阴道假丝酵母菌病阴道分泌物标本，应用法国生物梅里埃酵母菌鉴定试剂盒ID32C和药敏试剂盒ATBTM FUNGUS3进行鉴定和药敏试验。结果：108株假丝酵母菌中分离出光滑假丝酵母菌36例，白色假丝酵母菌35例，近平滑假丝酵母菌20例，热带假丝酵母菌7例，其他11例；对抗真菌药物AMB、5FC敏感性分别为96.30%、85.19%，对FCA、VRC、ITR耐药率分别为42.59%、50.93%、72.22%。有26株白色假丝酵母菌对3种三唑类药物均耐药。光滑假丝酵母菌对ITR耐药率高达83.33%。结论：复发性外阴阴道假丝酵母菌病的致病菌主要是光滑假丝酵母菌、白色假丝酵母菌，呈现非白假丝酵母菌占67.59%的分布特征，并且对AMB、5FC敏感性高，ITR耐药率高于VRC、FCA 【关键词】 假丝酵母菌病; 菌种; 敏感性; 耐药 Strains and drug susceptibility of vaginal candida in recurrent vulvovaginal candidiasis CHI Shaoqin?1, WANG Yuehong?1, XIE Dielan?2 1 Family Planning Service Centre of Longgang district, Guangdong Shenzhen 518172, China 2 The Central Hospital of Longgang District, Guangdong Shenzhen 518172, China 【Abstract】 Objectives: To investigate candida strains and drug susceptibility of the vaginal candida in recurrent vulvovaginal candidiasis(RVVC), and to provide reference to clinical treatment. Methods:The samples from 108 patients with recurrent vulvovaginal candidiasis were collected and their vaginal secretion are measured with bioMé rieux kit of ID32C for candida strains and with ATBTM FUNGUS3 kit for drug susceptibility test. Results: Among 108 cases of Candida there are 36 Candida glabrata cases , 35 Candida albicans cases, 20 Candida parapsilosis cases, 7 tropicalis cases, and 11 other Candidas cases. The sensitivities to AMB and 5FC, two kinds of antifungal drugs, are 96.30% and 85.19% respectively. Drug resistance rates to FCA, VRC and ITR, are 42.59%, 50.93% and 72.22% respectively. There were 26 Candida albicans resistant to all three triazoles. The drug resistance rate is up to 83.33% for Candida glabrata. Conclusions: Candida glabrata and Candida albicans were the main pathogenic fungi for recurrent vulvovaginal Candidiasis. The non-Candida albicans takes up 67.59% candida species, and they are sensitive to AMB and 5FC. The strains show a higher drug resistance rate to ITR than to VRC and FCA.