癫痫发作过程中迷走神经刺激对癫痫的抑制作用.pdfVIP

336 Neuroscience Bulletin November 30， 2007，23(6)：336—340．http：／／www．neurosci．ca ·Article· seizures in epileptic process ofrats Hong—Jun YANG ，Kai—Run PENG ，San—Jue HU ，Yan LIU。 Department of neurology,Guangzhou military general hospital,Guangzhou 510010,China 2Institute ofNeuroscience．The Fourth Military Medical University．xi’an 710032．China Abstract：0bjective Our previous work suggested that sensitivity of hippocampal neurons is changed in process of epileptic activities，and closely parallel to the dynamic characteristic of epileptic activity of the neurons．This study investigated the sensitivity of epileptic brain to vagal nerve stimulation(VNS)in epileptic process．Methods Epileptic model was evoked by penicillin．Left vagal nerves were stimulated to inhibit the seizures induced by penicillin．The electrocorticography(ECoG)and electromyography(EMG)were recorded to analyze inhibiting effect of VNS in epileptic process．Results It was found that VNS could inhibit the seizures caused by penicillin，and the inhibiting effect of VNS to seizures increased as the vagal nerve stimulating time prolonged．It was also found that the inhibiting effect of VNS to seizures decreased in epileptic process．Conclusion The results suggested that the sensitivity of epileptic brain to VNS was different in epileptic process．Th e inhibiting effect of VNS to seizure decreased as the development of seizures． Keywords：epilepsy；vagal nerve stimulation；chaos 1 Introduction Inourprevious research，wefouIndthat sensitivityofdorsal root ganglion(DRG)neurons to stimulus may depend on In recent years，vagal nerve stimulation(VNS)ha