牙槽骨骨密度与甲状腺激素的影响汇编.docVIP

牙槽骨骨密度与甲状腺激素的影响 张 翔1，邱泽文2，徐 晶1，曲 哲1，马 岚1，潘小青1，张丹迪1(1大连市口腔医院，辽宁省大连市 116021；2大连医科大学实验动物中心，辽宁省大连市 116021) 引用本文：张翔，邱泽文，徐晶，曲哲，马岚，潘小青，张丹迪. 牙槽骨骨密度与甲状腺激素的影响[J].中国组织工程研究，2016，20(42):6302-6307. DOI: 10.3969/j.issn.2095-4344.2016.42.011 ORCID: 0000-0001-8068-2766(张翔) 文章快速阅读： 文题释义： 牙槽骨：是上、下颌骨包围和支持牙根的部分，又称为牙槽突。容纳牙根的窝称牙槽窝，牙槽窝在冠方的游离端称为牙槽嵴，两牙之间的牙槽突部分称为牙槽中隔。牙槽骨的组织结构与身体其他骨相似，其生长发育依赖于牙的功能性刺激，当牙萌出时牙槽骨开始形成、增高，并提供形成中的牙周膜一个骨性附着面，牙槽骨在牙失去后逐渐吸收、消失。 骨质疏松症(OP)：是一种以骨量降低和骨组织微结构破坏为特征，导致骨脆性增加和易于骨折的代谢性疾病。临床上按病因可分为原发性和继发性2类。原发性又分状腺素50 μg/(kgd)生理盐水稀释，腹腔注射，对照组每日注射等量生理盐水。8周后检测FT3，FT4， 碱性磷酸酶，Ca，P，Mg指标；用双能X射线骨密度扫描仪检测腰椎、下颌骨及双侧股骨远心端骨密度，并进行相关性分析。 结果与结论：在给药8周后，①甲亢组兔血清FT3，FT4明显高于对照组；②甲亢组血清碱性磷酸酶，Ca，P，Mg均高于对照组，其中甲亢组血Ca显著高于对照组(P 0.01)；③甲亢组腰椎、下颌骨、左股骨、右股骨骨密度数值均显著低于对照组；④甲亢组下颌骨骨密度与椎骨和股骨的骨密度变化呈正相Thyroid hormones affect alveolar bone density Zhang Xiang1, Qiu Ze-wen2, Xu Jing1, Qu Zhe1, Ma Lan1, Pan Xiao-qing1, Zhang Dan-di1 (1Dalian Stomatological Hospital, Dalian 116021, Liaoning Province, China; 2Laboratory Animal Center, Dalian Medical University, Dalian 116021, Liaoning Province, China) Abstract BACKGROUND: Overproduction of thyroid hormones is shown to increase the activities of osteoblasts and osteoclasts, stimulating bone resorption and transformation. Inadequate compensation of increased bone resorption by bone transformation results in an increased loss of bone mass. OBJECTIVE: To investigate the effects of hyperthyroidism on the density of the alveolar bone. METHODS: Twenty-four New Zealand rabbits were equally randomized into hyperthyroidism group and control group. Rabbits in the hyperthyroidism group or control group were daily injected intraperitoneally with 50 μg/kg levothyrocine diluted in physiological saline solution or equal volume of physiological saline. At 8 weeks after treatment, serum levels of thyroid hormones (FT3 and FT4), alkaline phosphatase, magnesium and calcium, phosphorus were determined; meanwhile, the bone densities of the lumbar vertebra, mandible, bilateral distal