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M A T H E M A T I C SI N B I O L O G Y
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O V I E W P O I N T
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E Introductory Science and Mathematics Education
S
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I for 21st-Century Biologists
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E
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S William Bialek1,3 and David Botstein2,3*
Galileo wrote that “the book of nature is written in the language of mathematics”; These traditions have resulted in a deep
his quantitative approach to understanding the natural world arguably marks the bifurcation in culture and quantitative com-
beginning of modern science. Nearly 400 years later ,the fragmented teaching of petence among the scientific disciplines. On
science in our universities still leaves biology outside the quantitative and mathe- one branch are mathematics, the physical sci-
matical culture that has come to define the physical sciences and engineering. This ences, and engineering. Scientists educated
strikes us as particularly inopportune at a time when opportunities for quantitative along this branch achieve a high level of
thinking about biological systems are exploding. We propose that a way out of this quantitative expertise: They generally have
dilemma is a unified introductory science curriculum that fully incorporates math- some mastery over and comfort with not only
ematics and quantitative thinking. multivariate calculus and differential equa-
tions, but also linear algebra,
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