马来酸氟吡汀治疗急性腰扭伤疼痛的临床观察δ - 中国药房.pdf

马来酸氟吡汀治疗急性腰扭伤疼痛的临床观察Δ 1＊ 2# 陆海鹏 ，黄 格 （1.广西医科大学附属民族医院/广西壮族自治区民族医院药剂科，南宁 530001；2. 广西医 科大学附属民族医院/广西壮族自治区民族医院麻醉科，南宁 530001） 中图分类号 R969 文献标志码 A 文章编号 1001-0408（2015）29-4097-03 DOI 10.6039/j.issn. 1001-0408.2015.29.22 摘 要 目的：观察马来酸氟吡汀治疗急性腰扭伤疼痛的临床疗效和安全性。方法：选取急性腰扭伤患者60例，根据入院单双号 顺序分为试验组和对照组各30例。试验组患者服用马来酸氟吡汀胶囊，1粒/ 次，3次/d ；对照组患者服用洛芬待因缓释片，2片/ 次， 2次/d 。比较两组患者的视觉模拟评分、临床疗效和不良反应。结果：试验组患者治疗后视觉模拟评分显著低于对照组，差异有统 计学意义（t ＝2.375，P ＝0.013）；试验组患者临床疗效高于对照组，差异有统计学意义（u ＝9.431，P ＝0.024）；试验组的不良反应轻 2 微，与对照组比较差异无统计学意义（χ ＝0.131，P ＝0.717）。结论：马来酸氟吡汀治疗急性腰扭伤疼痛临床疗效好、安全性高。 关键词 马来酸氟吡汀；急性腰扭伤；疼痛 Clinical Observation of Flupirtine Maleate for Pain Caused by Acute Lumbar Sprain 1 2 LU Hai-peng ，HUANG Ge （1. Dept. of Pharmacy ，the Affiliated Minzu Hospital of Guangxi Medical University/ Minzu Hospital of Guangxi Zhuang Autonomous Region ，Nanning 530001，China ；2. Dept. of Anesthesiology ， The Affiliated Minzu Hospital of Guangxi Medical University/Minzu Hospital of Guangxi Zhuang Autonomous Region ，Nanning 530001，China ） ABSTRACT OBJECTIVE ：To observe clinical efficacy and safety of flupirtine maleate for pain caused by acute lumbar sprain. METHODS ：60 patients with acute lumbar sprain were selected and divided into trial group and control group according to even and odd-numbered admission order. Trial group received flupirtine maleate capsule ，1piece/time ，3times/d ；control group was giv- en codeine sustained-release tablet ，2 tablets/time ，2 times/d. The VAS score ，clinical efficacy and ADR were compared between 2 groups. RESULTS ：The VAS score of treatment group after treatment was significantly lower than that of control group ，with statis- tical significance （t ＝2.375，P ＝0.013）. The clinical efficacy of trial group was significantly higher than that of control group ，with statistical significance （u ＝9.431，P ＝0.0