_多聚谷氨酸水凝胶制备及生物安全性评价_王敬.pdfVIP

12 1 Journal of Clinical Rehabilitative Tissue Engineering Research January 1, 2008 Vol.12, No.1 * Preparation and biological security of the gamma-poly-glutamic acid hydrogel Wang Jing, Gao Pei, Shen Jing, Su Jian, Sun Qi-ling Abstract Key Laboratory of AIM: Nanometer wound dressing is compounded with nano-silver particles in clinic. With high anti-bacteria property, but it has bad Bio-resources and biocompatibility and pollution to environment, and cannot be degraded. This article investigates the dynamics of esterified - Eco-environment of Ministry of poly-glutamic acid and the optimal method of esterified -poly-glutamic acid hydrogel preparation, and assesses the biological Education, College of security of -poly-glutamic acid hydrogel to provide a new type hydrogel material for wound dressing and tissue-engineered Life Sciences, materials. Sichuan University, METHODS: Experiments were conducted in the Life Science College and High-Molecular Science and Engineering College, Chengdu 610064, Sichuan Province, Sichuan University from August 2006 to January 2007. Esterified -poly-glutamic acid was prepared by the - poly-glutamic China acid reacting to the esterification reagent in the N-pyrrolidone under the condition of 60 oil bath. - poly-glutamic acid hydrogel was prepared from the esterified - poly-glutamic acid monomers with initiator of azo-bis-iso-butyrynitrile and cross Wang Jing , linker of hydroxyethylmethacrylate under the conditions of 80 oil bath and the protection of N2. The biocompatibilit