- 1、本文档共4页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
卵巢癌相关转移基因的研究进展 - tumor - 肿瘤
肿瘤2014 年9 月第34 卷第9 期 TUM OR Vol. 34, September 2014 875
DOI: 10.3781/j .issn.1000-7431.2014.09.016
Copyright© 2014 by TUM OR
Review
综述 ·
卵巢癌相关转移基因的研究进展
朱银芳,谭布珍
南昌大学第二附属医院妇产科,江西南昌 330006
[摘要] 卵巢癌是死亡率较高的妇科恶性肿瘤,大部分患者就诊时已是晚期。卵巢癌的侵袭和转移是患者死亡
的主要原因之一,其发生过程复杂,涉及多个基因和多个因素的综合参与。近年来,随着对肿瘤转移研究的深
入,发现许多肿瘤转移相关基因在卵巢癌的侵袭和转移中具有重要作用。本文就肿瘤转移相关基因果蝇zeste 基
EZH 2 )、基质金属蛋白酶2 (metrix metalloproteinases-2 ,
因增强子人类同源物2 (enhancer of zeste homolog 2 ,
MMP -2 )、结肠癌转移相关基因1 (metastasis-associated in colon cancer-1,MACC 1 )、高迁移率族蛋白A2 (high
mobility group A2 ,HMGA 2 )在卵巢癌侵袭和转移过程中的研究进展作一综述。
[关键词] 卵巢肿瘤;肿瘤转移;基因
[中图分类号] R737.31 [文献标志码] A [文章编号] 1000-7431 (2014) 09-0875-04
Advances in research on ovarian cancer-related metastatic genes
ZHU Yin-fang, TAN Bu-zhen
Department of Obstetrics and Gynecology, Second Affiliated Hospital of Nanchang University, Nanchang 330006,
Jiangxi Province, China
[A BSTRA CT] Ovarian cancer is the disease with a high mortality in gynecologic malignant tumors.
Most patients had metastasis once diagnosed, and the invasion and metastasis are considered as the
main reasons contributing to patients’ death. The process of invasion and metastasis is complicated,
involving multiple genes and steps which are related to diverse elements. In recent years, with the more
and more research in the mechanism of tumor metastasis, it has found that a great deal of genes plays
a significant role in invasion and metastasis of ovarian cancer. In this paper, it reviews the important
advances about the role of enhancer of zeste homolog 2 (EZH 2), matrix metalloproteinase-2 (MMP-2),
metastasis-associated in colon cancer-1 (MACC 1) and hig
文档评论(0)