结核分枝杆菌感染动物模型概述及研究现状-上海中医药大学.PDF

中 国 病 原 生 物 学 杂 志 20113 63 # 220 # J ournal of Pathogen B iology March 2011, Vol.6, No.3 # # * 冯梅, 王易* * ( , 201203) = , , , = ; ; ; = R378.911 = A = 1673-5234(2011) 03-0220-03 [J our nal of Pathogen B iology . 2011 Mar; 6(3) : 220- 222.] Current state of research on animal models of mycobacterium tuberculosis infection FENG Mei, ANG Yi ( Dep ar tment of I mmunology and P athogen B iology , S hanghai Univ ersity of T CM , Shang H ai 201203, China = Abstract My cobacterium tuber culosis (MTB) is amajor causeof human tuberculosis. A suitable animal model of MTB infection must bepromptly established asa research tool sincethemechanismscausing tuberculosis andthe immune mech- anisms involved in the bodys responseto MTB areunclear. Thispaper compares someof the problems common to differ- ent rodent modelsof MTB infection already in use, which include animal strain selection, the route of infection, the infec- tive dose, and evaluation criteria. These issues reveal the current state of research on animal models of MTB infection. = Key words Tuberculosis; M y cobacter ium tuber culos is (MTB); animal model; review *** (M ycobacter ium tuber culosis , MTB) , [ 8] ,, 2008 ( ) 940 , 180 ( 50 , ), , (IES) , 5 ml (+ , ,