脂肪酸代谢与肿瘤靶向治疗新途径 - tumor.pdf

868 　　肿瘤2014 年9 月第34 卷第9 期　TUM OR Vol. 34, September 2014 DOI: 10.3781/j .issn.1000-7431.2014.09.015 Copyright© 2014 by TUM OR Review 综述 · 脂肪酸代谢与肿瘤靶向治疗新途径 1 2 3 赵　静 ，支　政 ，宋光耀 1. 河北省人民医院肿瘤科，河北 石家庄　050051 ；2 . 河北中医学院基础医学院医史文献教研室，河北 石家庄　 050200 ；3. 河北省人民医院内分泌科，河北石家庄　050051 [摘要]　脂肪酸从头合成的增强是肿瘤细胞具有标志性的代谢异常之一。从头合成是肿瘤细胞获得脂肪酸的主要 途径，并参与肿瘤细胞转化、增殖和迁移的各个方面。因此，脂肪酸合成通路的相关酶成为合理的抗肿瘤治疗靶 点。然而，最近的研究发现，抑制肿瘤细胞内源性脂肪酸合成而产生的抗肿瘤作用，可被添加外源性脂肪酸所逆转。 此外，大量摄入膳食脂肪是导致某些肿瘤进展及预后不良的潜在危险因素。因此，除了从头合成途径产生的脂肪酸， 某些肿瘤细胞还可以利用脂肪分解途径产生的脂肪酸来维持自身的增殖和存活。脂肪分解产生的脂肪酸可能是肿 瘤细胞获得脂肪酸的另一来源，脂肪分解途径将为抗肿瘤治疗提供新的靶点。本文就目前对肿瘤细胞脂代谢变化 的认识进行综述，探索靶向脂代谢通路的抗肿瘤治疗的新理论和新方向。 [关键词]　肿瘤；脂肪酸；代谢；靶向治疗 [中图分类号]　R730.5 [文献标志码] A [文章编号]　1000-7431 (2014) 09-0868-07 Fatty acid metabolism and novel targeted therapy of cancer 1 2 3 ZHAO Jing , ZHI Zheng , SONG Guang-yao 1. Department of Tumor, Hebei People’s Hospital, Shijiazhuang 050051, Hebei Province, China; 2. Department of History and Literature of Traditional Chinese Medicine, School of Basic Medical Sciences, Hebei College of Traditional Chinese Medicine, Shijiazhuang 050200, Hebei Province, China; 3. Department of Endocrinology, Hebei People’s Hospital, Shijiazhuang 050051, Hebei Province, China [ABSTRACT]　Enhanced de novo fatty acid (FA) synthesis is one of the most important metabolic hallmarkers of cancer cells. Increased FA synthesis has been considered as the major mean of FA acquisition in cancer cells, and involves various aspects of tumorigenesis and the proliferation and migration of tumor cells, therefore, enzymes in FA synthesis pathway become potential targets for anti-cancer therapy. However, recent studies have found that the cytotoxic effects caused