GeneX(Gene10基因十)--Chapter15.pptVIP

15.10 The Synaptonemal Complex Forms after Double-Strand Breaks 15.12 The Bacterial RecBCD System Is Stimulated by chi Sequences 15.23 Recombination Pathways Adapted for Experimental Systems 15.15 Eukaryotic Genes Involved in Homologous Recombination The MRX complex, Exo1, and Sgs1/Dna2 in yeast and the MRN complex and BLM in mammalian cells resect double-strand breaks. The Rad51 recombinase binds to single-stranded DNA with the aid of mediator proteins, which overcome the inhibitory effects of RPA. FIGURE 23: Structure of Rad50, MRX/N complex binding DSB Adapted from M. Lichten, Nat.