疏肝健脾化浊法治疗高脂血症的临床探究.pdfVIP

提 要 目的：观察疏肝健脾化浊法治疗高脂血症（肝郁脾虚血浊证）的临床疗效，并探 讨其作用机理。资料和方法：选择高脂血症(肝郁脾虚血浊证)病人 60 例，采用随机 分组的方法，分为治疗组和对照组两组，每组各 30 人，其中治疗组脱落 2 例，对照 组脱落1例。治疗组采用调脂降浊汤治疗；对照组采用血脂康胶囊，0.6g,每日两次,4 周为一个疗程。分别于治疗前后检测患者一般状况、血尿和大便常规、肝肾功能、血 脂、血管内皮功能、活化的部分凝血酶原时间、血浆凝血酶原时间、国际标准化比值、 纤维蛋白原等指标及患者症候变化情况。服药期间，定期观察中医症候改善情况，分 别采用等级积分及文字描述的方法，最后作统计学处理。结果：服用调脂降浊汤治疗 组症状改善总有效率为 92.86%,有效率 79.31%，与对照组相比较有显著性差异 (P0.05)；治疗组胆固醇（TC）、低密度脂蛋白（LDL-C）、 甘油三酯（TG）、载脂蛋 白 B(ApoB)明显降低，高密度脂蛋白（HDL-C）、载脂蛋白 A1(ApoA1)明显升高，与对 照组无统计学差异(P＞0.05）。治疗组脂蛋白α（Lp(a)）、内皮素-1（ET-1）明显降 低，一氧化氮（NO）明显升高 ，与对照组比较，有显著性差异(P0.05或0.01)。结 论：疏肝健脾化浊法治疗高脂血症疗效显著，并具有保护血管内皮，改善血液高凝状 态的作用。 关键词 高脂血症；肝郁脾虚血浊；疏肝健脾化浊；调脂降浊汤 Clinical Research on Hyperlipidemia Treated by the method of Smoothing Liver and strengthening spleen and relieving turbity Speciality：Internal Medicine of Traditional Chinese Medicine Author ：Pei Hongyang Tutor ：Prof. Gao Hongchun Abstract Objectives:To observe efficiency and adverse effects of Smoothing Liver and strengthening spleen and relieving turbity on the treatment of Hyperlipidemia and explore its mechanism of effect.Documents and Methods:Sixty patients with hyperlipidemia entered the study and were randomized to treatment and control group 30 cases in each.The treatment group was given ChaiShenZeTiaoZhi soup.The control group was givensimvastatin tablets.The treatment duration was four weeks.Blood fat、endothelial function、APTT 、TT、INR and fibrinogen and the changs of clinical symptom were determined at the beginning and the end of the trial respectively.During treatment we observed the improvement of Traditional Chinese Medicine Symptom ,adopted by method of grade score and described in words,and pr