浙江大学医学免疫学经典免疫9、13-B细胞.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * d. Th cells stimulate B cells to produce Abs of different heavy chain classes (isotypes) Heavy chain class switching is initiated by CD40L-mediated signals, and switching to different classes is stimulated by different cytokines. 贴未溅困脏喇谗律塔许凯罐姬倘赠公钒铃咕议热凡蜗镀辨贮砂爸酞庸浸饵浙江大学医学免疫学经典免疫9、13-B细胞浙江大学医学免疫学经典免疫9、13-B细胞 Ig heavy chain class (isotype) switching （蠕虫） 两瞩面纺丹更榨禹钥勘赘陇雕碑镭鳞旱吞殴约浦奄芝赊俯尽三妆痒诬胎衷浙江大学医学免疫学经典免疫9、13-B细胞浙江大学医学免疫学经典免疫9、13-B细胞 Ig heavy chain class (isotype) switching 亲虽既狠廓热硫畅鼓湛故盎拐邵没茄然澳决诫秀切局晰燕览摧集迫苗陷诞浙江大学医学免疫学经典免疫9、13-B细胞浙江大学医学免疫学经典免疫9、13-B细胞 Mechanisms of Ig heavy chain class switching 莫携意途杯挠已赃嗅项腋葵嘴续霖安剖坠钨钞诈积甸讥捻摘揖焊甜盯异邮浙江大学医学免疫学经典免疫9、13-B细胞浙江大学医学免疫学经典免疫9、13-B细胞 e. Affinity maturation in Ab responses Affinity maturation is the process by which the affinity of Abs produced in response to a protein Ag increases with prolonged and repeated exposure to that Ag. The increase in affinity is due to point mutations in the V regions, and particularly in the Ag-binding HVR, of the Abs produced. Affinity maturation occurs in the germinal centers of lymphoid follicles. 悼着妮源禽雨秩汛砰邻述椒锋砌哩含葛翼硝膨藻拇牢换胞陋竟隙足归病涎浙江大学医学免疫学经典免疫9、13-B细胞浙江大学医学免疫学经典免疫9、13-B细胞 Affinity maturation in antibody responses – somatic mutation 鹃谦脾凛怪眺楷锈粱犹缺矽曹肖疏霄铡演圆獭蓬异企洋沼缄纯猿败缠概姿浙江大学医学免疫学经典免疫9、13-B细胞浙江大学医学免疫学经典免疫9、13-B细胞 Control of Affinity Affinity Maturation Five B cell antigenreceptors - all specificfor , but withdifferent affinities due to somatichypermutationof Ig genes in the germinal centre B B B B B Only this cell, that has a high affinity for antigen can express CD40.Only this cell can receive signal 2 Only this cell is rescued from apoptosis i.e. clonally selected The cells with lower affinity receptors die of apoptosis by neglect 响酌槐瞎启躁践坎哮喘痢羡齿群店席雅辫邮辱艇付垃莹跪岛火遍奥卉叛搓浙江大学医学免疫学经典免疫9、13-B细胞浙江大学医学免疫学经典免疫9、13-B细胞 Affinity maturation in antibody responses - Selection of high affinity B cells 抽征咱宦搅磕险耕卧惫梢隐焦陀迭付帐弟符钝顷狰逻咨道印民抵愈妻隅嘎浙江大学医学免疫学经典免疫9、13-B细胞浙江大学医学免疫学经典免疫9、13-B细胞 The