来曲唑和克罗米酚对PCOS的促排卵及妊娠结局的比较研究.pdfVIP

章汉旺等 来曲唑和克罗米酚对PCOS的促排卵及妊娠结局的比较研究 第6期 · 825· · 生殖健康 · 来曲唑和克罗米酚对PCOS的促排卵及妊娠结局的比较研究 章汉旺 李 莉 华中科技大学同济医学院附属同济医院生殖中心(湖北 武汉) 430030 中国图书分类号 R714．12 文献标识码 A 文章编号f2008)06-0825-03 【摘 要】 目的：比较来曲唑和克罗米酚对PCOS的促排卵及妊娠结局，旨在寻找一种新的促排卵药物。方法：拟行促排 卵治疗的多囊卵巢综合征 (PCOS)患者66例，分为来曲唑组20例和克罗米酚组46例。来曲唑组 (I )从月经第3—7天给与 LE 5．0 mg／d口服，第7天加用尿促性腺激素 (HMG)至HCG日；克罗米酚组 (cc)从第5—9天给与CC 100 mg／d口服，第6 天加用HMG至HCG日。于HCG日观察≥14 mm卵泡数、≥16 mm卵泡数、子宫内膜厚度、形态和血清E，、LH、T水平以及排 卵后第7天血清E：、P水平。记录妊娠率、流产例数、异位妊娠例数和OHSS发生例数。结果：尽管HCG日LE组E：水平显著 性的低于CC组 (P0．01)，但是子宫内膜的厚度和形态两组无差异。然而CC组中有13例患者HCG日子宫内膜厚度7．0 mm，LE组中无1例。与CC组相比，HCG日LE组≥14 mm数明显减少 (P0．05)，且无1例卵巢过度刺激综合征 (OHSS) 的发生。I 组妊娠率和继续妊娠率都高于CC组，但无统计学意义。结论：LE有类似CC的促排卵作用及相似的妊娠率。 【关键词】 来曲唑 克罗米酚 PCOS促排卵 A comparison of the effects and pregnancy outcome of letrozole versus clomiplhene citrate for ovulation induction in women with polycystic ovarian syndrome ZHANG Han—Wang，LI Li．Reproductive Medicine Center of Tongji Hospital，Tongji medical College，Huazhong Univer- sity ofScience and Technology，Wuhan 430030，Hubei，China [Abstract Objective：To search for a new drug for ovulation induction through a comparison of the effects and pregnancy outcome of letrozole(LE)versus clomiphene citrate(CC)for induction of ovulation．Methods：The patients with polycystic ovarian syndrome(P． COS)undergoing ovarian stimulation were divided into LE group and CC group．All subjects received either LE at a dosage of 5．0mg daily from cycle day 3 to 7 plus HMG injection staring on day 7 or CC(100mg／day)from day 5 to day 9 plus HMG injection on day 6 until the day of HCG．The number of follicle≥14 mm and follicle≥16 mm．endometrial thickenss and pattern were observed on the day of HCG． Some samples were analyzed including serum E2，testosterone and LH on the day of HCG and E2 and