临床研究设计分析与文章写作.ppt

Clinical Study Design, Analysis, and Presentation;Study Design (科研设计);Overview;Key issues in study Design (研究设计的关键）;Fundamental Study Design(基本研究设计类型）;Any clinical study published in the Medical Journals ;大气污染与糖尿病发生率的关系;Summary （总结） ;Study Population;临床资料充分;临床资料充分;Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Hum Mol Genet. 2009 Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care. 2009 Jul;32(7):1278-83. RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. J Lipid Res. 2009 Jul;50(7):1479-86. Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population. Diabetologia. 2009 May;52(5):834-43. Associations of inflammatory factors with glycaemic status among middle-aged and older Chinese people. Clin Endocrinol (Oxf). 2009 Jun;70(6):854-62. Epub 2008 Sep 2. Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese. Eur J Endocrinol. 2008 Nov;159(5):585-93. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes. 2008 Oct;57(10):2834-42. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes. 2008 Jan;57(1):264-8. Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab. 2007 Dec;92(12):4827-34. ;Common Disease （常见病的研究）;小型病例对照研究;ALS （肌萎缩性脊髓侧索硬化症 ）;Randomized Clinical Trial Design(随机临床试验设计）;Times cited （累积引用次数）: Google: 1,906 ISI: 1,048 ;20,000 Men and Women will be Randomized in the VITAL Trial;8171 Women Randomized in the WACS Trial