抗CD20 抗体治疗非霍奇金淋巴瘤 - 中国医药生物技术.PDF

140 2009 4 4 2 Chin Med Biotechnol, April 2009, Vol. 4, No. 2 ·· CD20 non-hodgkin’s lymphoma NHL B 375 mg/m2 B 1 4 10 NHL 1 g [1] 2 2 80% NHL 1997 CD20 —— NHL 15% 10 [6] 1 NHL CD20 –CD20 B CD20 B BCR FDA [2] 166 [7] 50% 6% Fc 1 70 CD20 3% 50%[8] CD20 CD20 1 70% 1 ~ 2.5 [9-11] 70% ~ 80% 1.5 ~ 2 [12-13] [14-15]