2型糖尿病肾病患者高半胱氨酸、C反应蛋白联合检测临床意义.doc

2型糖尿病肾病患者高半胱氨酸、C反应蛋白联合检测临床意义[摘要] 目的 探讨2型糖尿病肾病患者高半胱氨酸、C反应蛋白联合检测的临床意义。方法 检测36例2型糖尿病肾病患者高半胱氨酸、C反应蛋白水平，并选择同期行健康体检者作为对照组进行比较分析。结果 DN组Hcy、CRP、UAE水平明显高于对照组，两组比较差异有统计学意义（P＜0.05或P＜0.01）。经直线相关分析显示，血清Hcy、CRP与MAU呈显著正相关（r=0.721、0.542，P＜0.01）。结论 血清Hcy、CRP浓度在DN患者中显著升高，且与UAE呈正相关，它们与DN发生发展有关。对糖尿病并发DN的早期诊断、病情发展的分析和监测有一定的临床意义，对糖尿病未来风险的预见及临床治疗的有效性评估提供了一定的参考价值。 [关键词] 2型糖尿病肾病；高半胱氨酸；C反应蛋白；联合检测 [中图分类号] R587.2 [文献标识码] B [文章编号] 1673-9701（2011）31-82-02 The Clinical Significance of High Homocysteine and C-reactive Protein Combined Detection in Type 2 Diabetic Patients HE Yunxiao Department of Laboratory, Tiantai Chinese Medicine Hospital in Zhejiang Province，Tiantai 317200, China [Abstract] Objective To investigate the clinical significance of high homocysteine and C-reactive protein combined detection in type 2 diabetic patients. Methods Thirty six cases of type 2 diabetic patients with high homocysteine, C reactive protein level, and the same row selected as the healthy control group were analyzed. Results DN group of Hcy, CRP, UAE levels were significantly higher, and the differences were statistically significant (P＜0.05 or P＜0.01). The linear correlation analysis showed that serum Hcy, CRP and MAU were significantly correlated (r=0.721, 0.542, P＜0.01). Conclusion Serum Hcy, CRP concentrations are significantly higher in DN patients, and are positively correlated with the UAE, concerned with the development of DN. They have clinical significance for the early diagnosis of diabetes mellitus combined with DN, analysis and monitoring of progression of the disease, and have a certain reference value for the expected future risk of diabetes and clinical evaluation of the effectiveness. [Key words] Type 2 diabetic nephropathy; Homocysteine; C-reactive protein; Combined detection 糖尿病肾病（diabetic nephropathy，DN）是2型糖尿病（type 2 diabetes mellitus，T2DM）全身微血管并发症之一，发病较隐匿，临床确诊较困难，且早期尿白蛋白定性实验多为阴性。高半胱氨酸（Hcy）是微血管病变的重要指标之一，糖尿病肾病患者由于肾小球滤过功能受损，致体内高半胱氨酸蓄积，其在糖尿病肾病患者血清浓度的升高提示病变的进一步发展[1]。C